Aspirin Complex, sachets 3.5 g, 10 pcs.

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Product Description


1 sachet (3.5475 g) active ingredients:

acetylsalicylic acid - 500 mg,

phenylephrine hydrotartrate - 15.58 mg,

chlorphenamine maleate - 2.00 mg;


anhydrous citric acid 1220 mg,

sodium bicarbonate 1709.6 mg,

lemon flavor 100 mg,

quinoline yellow dye (E 104) 0.32 mg.

pharmachologic effect

Aspirin Complex - a combined drug.

Acetylsalicylic acid has an antipyretic, analgesic and anti-inflammatory effect, and also reduces platelet aggregation. 

Phenylephrine is a sympathomimetic and, having a vasoconstrictor effect, reduces swelling of the mucous membranes of the nose and paranasal sinuses, which makes breathing easier.

Chlorphenamine - a blocker of histamine H1 receptors, has an anti-allergic effect: eliminates itching (including the eyes, nose), swelling and hyperemia of the mucous membranes of the nasal cavity, nasopharynx and sinuses, reduces the effects of exudation.


Symptomatic treatment of influenza, SARS, and other colds accompanied by fever, chills, headache, muscle pain, runny nose and / or nasal congestion, sore throat, and sneezing.

Pregnancy and lactation

Contraindicated in breastfeeding and pregnancy.


  • acute and recurrent erosive and ulcerative diseases of the gastrointestinal tract;
  • hemorrhagic diathesis;
  • bronchial asthma induced by taking salicylates and NSAIDs;
  • combined use with methotrexate at a dose of 15 mg per week;
  • renal failure;
  • liver failure;
  • severe heart failure in the stage of decompensation;
  • arterial hypertension;
  • angina pectoris;
  • thyroid enlargement;
  • I and III trimesters of pregnancy;
  • lactation (breastfeeding);
  • hypersensitivity to acetylsalicylic acid, other salicylates or any components of the drug.

The drug is not prescribed for children under 15 years of age with acute respiratory infections caused by viral infections, due to the risk of Reye syndrome (encephalopathy and acute fatty liver with acute development of liver failure).

With caution, the drug should be prescribed for gout, hyperuricemia; in patients with a history of indications of gastrointestinal ulcerative lesions (including gastric and duodenal ulcers) or gastrointestinal bleeding, impaired renal and hepatic function, bronchial asthma, chronic respiratory diseases, hay fever, nasal mucosa polyposis ; with allergic reactions to drugs (including NSAIDs), in the second trimester of pregnancy.

Side effects

Acetylsalipilic acid

Body as a whole: hyperhidrosis.

Gastrointestinal tract: nausea, dyspepsia, vomiting, stomach ulcers and 12 duodenal ulcer; gastrointestinal bleeding, including hidden (black stool).

Allergic reactions: urticaria; eczematous skin rash; angioedema (Quincke's edema), runny nose, bronchospasm and shortness of breath.

Hematopoietic system: hypoprothrombinemia.

Central nervous system and sensory organs: dizziness, tinnitus, headache, hearing loss.

Urinary system: renal failure, acute interstitial glomerulonephritis. In rare cases (


Central nervous system and sensory organs: headache; dry mouth, insomnia, nausea, irritability, anxiety.

In rare cases:

Central nervous system: severe headache, inappropriate behavior. 

Cardiovascular system: increased blood pressure, tachycardia.

Urinary system: painful or difficult urination.


Body as a whole: dry mouth; dry mucous membranes of the mouth and nose, impaired accommodation (blurred vision).

Cardiovascular system: tachycardia.

Gastrointestinal tract: constipation.

Urinary system: urinary retention, difficulty and pain when urinating.

Central nervous system and sensory organs: impaired attention, drowsiness, dizziness.

In children and elderly patients are possible: lethargy, agitation, dizziness, anxiety, irritability.

If any adverse reactions occur, stop taking the drug and consult a doctor


Acetylsalicylic acid

Combination with methotrexate at a dose of> 15 mg per week is contraindicated. Combinations of drugs that are used with caution: Methotrexate in a dose of less than 15 mg / week: With the simultaneous use of drugs, the hematological toxicity of methotrexate is increased due to the fact that NSAIDs generally reduce the renal clearance of methotrexate, and salicylates, in particular, displace it from plasma proteins .

Anticoagulants (coumarin, heparin): while taking ASA and indirect aticoagulants, the risk of bleeding increases due to suppression of platelet function, damage to the mucous membrane of the stomach and duodenum, and displacement of oral anticoagulants from their association with plasma proteins.

Other NSAIDs with salicylates in a high dose (at a dose of 3 g / day or more): with the simultaneous use of drugs due to the synergistic effect, the risk of forming ulcers of the gastrointestinal tract and bleeding increases.

Uricosuric drugs (probenecid, sulfinpyrazone): the therapeutic effect of uricosuric drugs is reduced due to competitive tubular elimination of uric acid.

Digoxin: with the simultaneous use of drugs, the concentration of digoxin in plasma increases due to a decrease in its excretion.

Antidiabetic drugs (insulin, sulfonylurea): the hypoglycemic effect is enhanced due to the fact that ASA in a high dose has hypoglycemic properties and displaces sulfonylurea from the connection with plasma proteins.

Thrombolytics / antiplatelet drugs of other classes (ticlopidine): increased risk of bleeding.

Diuretics in combination with ASA at a dose of 3 g / day or more: glomerular filtration decreases, due to a decrease in the synthesis of prostaglandins in the kidneys.

Systemic glucocorticosteroids (GCS) with the exception of hydrocortisone (used to treat Addison's disease): with the simultaneous use of drugs, the concentration of salicylates in the blood decreases, since GCS enhances the elimination of salicylates.

Angiotensin-converting enzyme (ACE) inhibitors: with the simultaneous use of ACE inhibitors and ASA at a dose of 3 g / day or more, a decrease in the hypotensive effect of ACE inhibitors is noted due to a decrease in glomerular filtration.

Valproic acid: ASA disrupts the connection of valproic acid with plasma proteins, resulting in increased toxicity.

Alcohol: when combined with ASA, the damaging effect on the mucous membrane of the gastrointestinal tract is enhanced and the bleeding time is lengthened.


Monoamine oxidase inhibitors (MAO inhibitors) - with the simultaneous use of phenylephrine and MAO inhibitors (antidepressants - tranylcypromine, moclobemide; antiparkinsonian drugs - selegiline), severe side effects may occur in the form of intense headache, increased blood pressure and body temperature.

Beta-blockers - with simultaneous use, an increase in blood pressure (arterial hypertension) and severe bradycardia are possible. Sympathomimetics with simultaneous use increases the effect of sympathomimetics on the central nervous system and the cardiovascular system. Excitement, irritability, insomnia are possible.

Inhalation anesthetics - the use of filylephrine before inhalation anesthesia increases the risk of heart rhythm disturbance. Phenylephrine should be discontinued a few days before the planned surgical treatment.

Rauwolfia alkaloids - with simultaneous use, the therapeutic effect of phenylephrine may be reduced.

Caffeine - with simultaneous use, the therapeutic and toxic effects of caffeine may be enhanced.

Indomethacin, bromocriptine - in isolated cases, with the simultaneous use of phenylephrine with indomethacin or bromocriptine, severe arterial hypertension is possible.

Selective serotonin reuptake inhibitors - with simultaneous use with antidepressants of this group (fluvoxamine, paroxetine, sertraline), both the body's sensitivity to sympathomimetics and the risk of developing a serotonergic effect may increase.

Antihypertensive drugs from the group of sympatholytics, such as reserpine, guanethidine - phenylephrine, reduce the hypotensive effect of these drugs.


Alcohol, sleeping pills, tranquilizers, antipsychotics (antipsychotics), neutral analgesics - chlorphenamine can enhance the inhibitory effect of these drugs on the central nervous system.

Anticholinergic drugs (atropine, antispasmodics, tricyclic antidepressants, MAO inhibitors, antiparkinsonian drugs) - chlorphenamine enhances the anticholinergic effect of these drugs.

How to take, course of administration and dosage

Adults and children over 15 years of age are prescribed 1 sachet every 6-8 hours. The maximum daily dose is 4 sachets, the interval between doses of the drug should be at least 6 hours.

The duration of treatment (without consulting a doctor) should not exceed 5 days when used as an anesthetic and more than 3 days as an antipyretic.

The drug should be taken orally after a meal, after dissolving the contents of the sachet in a glass of water at room temperature.


Symptoms: nausea, vomiting, ringing in the ears, hearing and vision impairment, rapid breathing, severe headache, imbalance, severe drowsiness, heart rhythm disturbance.

Treatment: gastric lavage, the appointment of activated carbon, symptomatic therapy.

Special instructions

Acetylsalicylic acid can cause bronchospasm, an attack of bronchial asthma, or other hypersensitivity reactions. Risk factors are the presence of asthma, nasal polyps, fever, chronic bronchopulmonary diseases, a history of allergies (allergic rhinitis, skin rashes).

Acetylsalicylic acid can increase bleeding tendency due to its inhibitory effect on platelet aggregation. This should be considered when surgery is necessary, including such minor interventions as tooth extraction. Before surgery, to reduce bleeding during surgery and in the postoperative period, you should stop taking the drug for 5-7 days and notify the doctor. Children should not be prescribed drugs containing acetylsalicylic acid, since in the case of a viral infection, the risk of Reye syndrome increases. Symptoms of Reye's syndrome include prolonged vomiting, acute encephalopathy, and enlarged liver.

During treatment, it is not recommended to drink alcohol because of the increased risk of side effects from the gastrointestinal tract associated with the intake of acetylsalicylic acid, and increased sedative effect of chlorphenamine.

Due to the fact that when using chlorphenamine, a change in the performance of skin allergic tests is possible, it is recommended to inform the doctor about the use of the drug and cancel it three days before the skin tests.

During treatment, it is not recommended to use painkillers, sympathomimetics, guanethidine and beta-blockers.

It is not recommended to take the drug systematically and for prophylactic purposes before vaccination.

Patients who limit salt intake should be aware that each bag contains sodium bicarbonate.

The active component phenylephrine, which is part of the drug, can cause a positive result when conducting a doping test in athletes.

With renal failure and low plasma albumin, the risk of a toxic effect of the drug increases.

Release form

Effervescent powder for oral solution

Storage conditions

At a temperature not exceeding 25 ° C

Shelf life

4 years

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